Transaction Details

Footnotes

Represents the weighted average price of the shares sold ranging from a low of $642.595 to a high of $643.47 per share. The undersigned undertakes, upon request by the Commission staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares purchased at each separate price. | Represents the weighted average price of the shares sold ranging from a low of $643.65 to a high of $644.47 per share. The undersigned undertakes, upon request by the Commission staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares purchased at each separate price. | Represents the weighted average price of the shares sold ranging from a low of $644.75 to a high of $645.60 per share. The undersigned undertakes, upon request by the Commission staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares purchased at each separate price. | Represents the weighted average price of the shares sold ranging from a low of $645.80 to a high of $646.71 per share. The undersigned undertakes, upon request by the Commission staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares purchased at each separate price. | Represents the weighted average price of the shares sold ranging from a low of $646.825 to a high of $647.69 per share. The undersigned undertakes, upon request by the Commission staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares purchased at each separate price. | Represents the weighted average price of the shares sold ranging from a low of $648.02 to a high of $649.00 per share. The undersigned undertakes, upon request by the Commission staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares purchased at each separate price. | Represents the weighted average price of the shares sold ranging from a low of $649.05 to a high of $649.72 per share. The undersigned undertakes, upon request by the Commission staff, the issuer or a security holder of the issuer, to provide full information regarding the number of shares purchased at each separate price. | Grant of option to buy 1,476 shares of Issuer common stock that vested on February 14, 2021. | Grant of option to buy 11,345 shares of Issuer common stock that vested in five annual installments beginning on February 14, 2017.