Transaction Details

Footnotes

Transaction made pursuant to Dr. Leiden's company approved trading plan under Rule 10b5-1, which was entered into on 8/6/2025. | Dr. Leiden undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. | Open market sales reported on this line occurred at a weighted average price of $440.40 (range $440.04 to $441.00). | Open market sales reported on this line occurred at a weighted average price of $441.26 (range $441.14 to $442.00). | Open market sales reported on this line occurred at a weighted average price of $443.21 (range $442.94 to $443.93). | Open market sales reported on this line occurred at a weighted average price of $444.36 (range $444.00 to $444.94). | Open market sales reported on this line occurred at a weighted average price of $445.56 (range $445.00 to $445.82). | Open market sales reported on this line occurred at a weighted average price of $447.05 (range $447.00 to $447.23). | Open market sales reported on this line occurred at a weighted average price of $448.78 (range $448.18 to $449.12). | Open market sales reported on this line occurred at a weighted average price of $449.84 (range $449.22 to $450.18). | Open market sales reported on this line occurred at a weighted average price of $451.20 (range $450.71 to $451.70). | Open market sales reported on this line occurred at a weighted average price of $452.20 (range $451.73 to $452.69). | Open market sales reported on this line occurred at a weighted average price of $453.34 (range $452.91 to $453.70). | Open market sales reported on this line occurred at a weighted average price of $455.22 (range $454.88 to $455.66). | Fully vested.