Transaction Details

Footnotes

Transaction made pursuant to Dr. Kewalramani's company approved trading plan under Rule 10b5-1, which was entered into on 11/17/2025. | Dr. Kewalramani undertakes to provide (upon request by the SEC staff, the issuer or a security holder of the issuer) full information regarding the number of shares sold at each separate price. | Open market sales reported on this line occurred at a weighted average price of $479.75 (range $479.75 to $479.76). | Open market sales reported on this line occurred at a weighted average price of $481.50 (range $481.50 to $481.51). | Open market sales reported on this line occurred at a weighted average price of $482.84 (range $482.84 to $482.85). | Open market sales reported on this line occurred at a weighted average price of $487.13 (range $486.64 to $487.55). | Open market sales reported on this line occurred at a weighted average price of $488.27 (range $487.82 to $488.56). | Open market sales reported on this line occurred at a weighted average price of $489.32 (range $489.01 to $489.79). | Open market sales reported on this line occurred at a weighted average price of $490.54 (range $490.10 to $491.01). | Open market sales reported on this line occurred at a weighted average price of $491.30 (range $491.13 to $491.85). | Open market sales reported on this line occurred at a weighted average price of $493.29 (range $492.78 to $493.77). | Open market sales reported on this line occurred at a weighted average price of $494.33 (range $493.78 to $494.75). | Open market sales reported on this line occurred at a weighted average price of $495.38 (range $494.79 to $495.78). | Open market sales reported on this line occurred at a weighted average price of $496.16 (range $495.79 to $496.74). | Open market sales reported on this line occurred at a weighted average price of $496.95 (range $496.79 to $497.17).