Transaction Details

Footnotes

Issued pursuant to the Second Amended and Restated Non-employee Director Compensation Policy, effective January 1, 2024. | The number of shares deemed indirectly beneficially owned by Dr. Denner decreased due to the termination of the investment advisory agreement with respect to a separately managed account. | Consists of shares that are held by Sarissa Capital Management LP ("Sarissa Capital") or by the funds and other investment vehicles (the "Sarissa Funds") for which Sarissa Capital serves as investment advisor. Dr. Denner is the Chief Investment Officer of Sarissa Capital and the managing member, general partner or other control party of the Sarissa Funds. By virtue of the foregoing, Dr. Denner may be deemed to indirectly beneficially own the shares that these funds directly beneficially own. Each of Sarissa Capital, the Sarissa Funds and Dr. Denner disclaims beneficial ownership of these shares except, in each case, to the extent of their pecuniary interest therein.