Transaction Details

Footnotes

This transaction was made pursuant to a Rule 10b5-1 (c) trading plan adopted by the Reporting Person on August 14, 2025. | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $451.41 to $451.84. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $454.92 to $455.45. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $455.97 to $456.94. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $457.00 to $457.98. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $458.01 to $458.94. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $459.40 to $460.36. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $460.46 to $461.40. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $461.50 to $462.39. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. | The price reported represents the weighted average sales price of shares sold in multiple transactions at prices ranging from $462.82 to $463.46. The reporting person will provide to the issuer, any security holder of the issuer or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. | Reflects shares of ALNY common stock acquired by the Reporting Person under the issuer 401(k) plan as a result of the issuer 401(k) matching contribution program. | This stock option was fully vested and exercisable as of December 1, 2021.