Transaction Details

Footnotes

Ordinary shares, nominal value 0.001 GBP per share ("Ordinary Shares"), are held in the form of American Depositary Shares ("ADSs"). Each ADS represents 1 Ordinary Share. | The reported transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 11, 2025. | Represents weighted average sales price. The shares were sold at prices ranging from $160.00 to $160.96. The reporting person will provide upon request, to the SEC, the Issuer or security holder of the Issuer, full information regarding the number of shares sold at each separate price. | Represents weighted average sales price. The shares were sold at prices ranging from $161.00 to $161.91. The reporting person will provide upon request, to the SEC, the Issuer or security holder of the Issuer, full information regarding the number of shares sold at each separate price. | Represents weighted average sales price. The shares were sold at prices ranging from $162.99 to $163.01. The reporting person will provide upon request, to the SEC, the Issuer or security holder of the Issuer, full information regarding the number of shares sold at each separate price.